Back in middle school after summer vacation, Greg Heffley and his older brother Rodrick must deal with their parents' misguided attempts to have them bond.

Ramona is a little girl with a very big imagination and a nose for mischief. Her playful antics keep everyone in her loving family on their toes, including her older sister Beezus, who's just trying to survive her first year of high school. Through all the ups and downs of childhood, Ramona and Beezus learn that anything's possible when you believe in yourself and rely on each other.