Teenager Cleo's school science project goes quite awry, causing her popular older sister Molly to go invisible.

It's a jungle out there for Blu, Jewel and their three kids after they're hurtled from Rio de Janeiro to the wilds of the Amazon. As Blu tries to fit in, he goes beak-to-beak with the vengeful Nigel, and meets the most fearsome adversary of all: his father-in-law.