Bodies are turning up around the city, each having met a uniquely gruesome demise. As the investigation proceeds, evidence points to one suspect: John Kramer, the man known as Jigsaw, who has been dead for over 10 years.

The series is a prequel, featuring the high school years of Flint Lockwood, the eccentric young scientist in the films. In his adventures, he will be joined by Sam Sparks, a new girl in town and the school's "wannabe" reporter, along with Flint's dad Tim, Steve the Monkey, Manny as the head of the school's audiovisual club, Earl as a school gym teacher, Brent as a baby wear model, and Mayor Shelbourne, who wins every election on the pro-sardine platform.

The supernatural phenomenon begins again with a fresh crop of inspiring heroes who take on the ultimate struggle between those with extraordinary abilities and those with nefarious motives to hunt and harness their powers. Epic adventures await these newly empowered allies as they cross paths with some of the original characters, unlocking the mysterious fate of the universe and their place within it.