An aristocratic Englishwoman, Lady Cornelia Locke, arrives into the new and wild landscape of the West to wreak revenge on the man she sees as responsible for the death of her son.

Set in a 19th century village, a young man studying under a local doctor joins a team of hunters on the trail of a wolf-like creature.

When human forces discover the existence of the Vampire and Lycan clans, a war to eradicate both species commences. The vampire warrior Selene leads the battle against humankind.