A westerner named Casey, studying Ninjutsu in Japan, is asked by the Sensei to return to New York to protect the legendary Yoroi Bitsu, an armored chest that contains the weapons of the last Koga Ninja.

When their transfer bus crashes in a West Virginia forest, a group of convicts and one a corrections officer meet a rafter who is on the run from cannibalistic hillbillies who have murdered her friends.

Duff Daniels steals a rare snake from a Native American dealer. The situation becomes worse when the snake goes on a killing spree, eating humans and animals alike.